Histamine, sex and orgasms: How histamine can increase orgasms and reduce sexual drive.

Contents

• Histamine and premature ejaculation
• Histamine, Dopamine and Orgasms
• The link between dopamine and histamine
• Importance of balancing histamine with sex
• 3 simple ways to manage your histamine
• Scientific references

Histamine can not only increase the intensity of an orgasm but can also decrease sexual drive. This is why it is important to balance your histamine.

Sex is becoming an increasing topic in the world. With new products to increase orgasm to even ones to delay sensitivity and orgasm. It's an interesting topic, especially in 2022 when researchers began looking at the involvement of histamine and premature ejaculation [1].

Histamine and premature ejaculation 

A study done in 2022 looked at the involvement of the H3 receptor and premature ejaculation [1]. The H3 receptor controls and functions in our central nervous system [5]. In particular, they looked at imetit a drug designed to increase histamine and the antihistamine Ciproxifan. 

This study was a very interesting read, the researchers concluded that increased histamine prolonged ejaculation whereas taking an antihistamine reduced the effects of histamine resulting in premature ejaculation. 

However, what was interesting is the study discussed the H1 receptor. That's the receptor your over the counter antihistamine blocks histamine from. The study found, that histamine was needed to trigger and induce the erection as histamine is involved with vasodilation i.e. when your blood vessels open up.

This study thus showed how histamine plays a major role in sexual function and could increase sensitivity leading to premature ejaculation. This is why it is important to have balanced histamine levels.

Our experts recommend using histamine binders such as zeolite clinoptilolite products to support your histamine detox and make sure your histamine levels are balanced. Check out even more educational articles and videos.

Histamine, Dopamine and Orgasms

During sexual arousal, histamine is released from mast cells surrounding the genitals. This allows the blood vessels to dilate and increases blood flow. For men it increases the erection and for women increasing the clitoral size and sensitivity. Histamine is essential in the body as it also increases our heart rate to help with energy and also supports with the intensity of an orgasm.

Interestingly histamine triggers the release of nitric oxide [2]. Nitric oxide is commonly found during an immune response as it stops the mast cells from degrading to quickly but also supports with increasing the blood flow and sensitivity to the genital area which ultimately supports with more intense orgasms.

Histamine as mentioned above increases the blood vessels, this in turn makes the genital area more sensitive which can support with potentially more intense orgasms. However, it can also lead to hypersensitivity making it uncomfortable as well.

The link between dopamine and histamine

Histamine and dopamine are intwined in an interesting way, what we know is there is a complex reaction between both. To simply put it, histamine will help release dopamine which is what makes us feel motivated, calm and even more focused [3,4]. So as you orgasm, your body will release the neurotransmitter dopamine making you feel more relaxed and motivated. In addition, we can't forget serotonin, which as many know regulates our mood and also helps control our deep sleep cycle. This is why post orgasm, we feel relaxed, happy and can begin to feel sleepy. As serotonin, dopamine reduce histamine. As we know histamine in the brain triggers the H3 receptor which is what help wake us up after sleep [5].

What this means lower histamine, better sleep. The research also suggests that as we increase dopamine and serotonin we can support with our histamine levels and thus histamine reactions.

Importance of balancing histamine with sex

It's interesting, what the research shows us is that histamine balance is extremely important in sexual function [1]. Not enough histamine and you may find it not only difficult achieving orgasm, but also reduced blood flowing to the genital area. However, too much histamine can lead to hypersensitivity and also could lead to premature ejaculation.

When looking at this, it is important to understand that histamine needs to be balanced. We understand and know histamine is beneficial during sex, as it can support with increased and more intense orgasms. It is important to detox histamine correctly, and support the body in detoxing histamine to make sure you are not hyper sensitive and finish quicker then you would like!

3 simple ways to manage your histamine

1. Look at your diet: Histamine foods aren't bad, but we know when we have too much histamine we can become reactive to these foods. So it is important to maintain a diet that's packed full of protein, fibre and nutrients which help increase energy. By taking out the high histamine foods, detoxing and reintroducing you can help support a balanced diet.
2. Detox histamine: Yes, we would suggest using a histamine binder which can help detox histamine. By detoxing excess histamine, you can begin to take control of your histamine levels.
3. Manage stress: Chronic stress will not only impact histamine i.e. increasing it, but also decrease happy hormones. Looking at breathing techniques, meditation and even addressing stress triggers can help keep your histamine levels at bay.

The role of histamine and sex is fascinating, the ability of histamine to potentially increase the intensity of an orgasm, shows the need of histamine in the body. Histamine isn't bad, but too much histamine is what causes the issue! 

It's time to get your histamine levels back into balance.

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Scientific references

1.  Kiyohara K, Uta D, Nagaoka Y, Kino Y, Nonaka H, Ninomiya-Baba M, Fujita T. Involvement of Histamine H3 Receptor Agonism in Premature Ejaculation Found by Studies in Rats. Int J Mol Sci. 2022 Feb 18;23(4):2291. doi: 10.3390/ijms23042291. PMID: 35216402; PMCID: PMC8878335.
2. Coleman JW. Nitric oxide: a regulator of mast cell activation and mast cell-mediated inflammation. Clin Exp Immunol. 2002 Jul;129(1):4-10. doi: 10.1046/j.1365-2249.2002.01918.x. PMID: 12100016; PMCID: PMC1906415.
3. Melis MR, Argiolas A. Dopamine and sexual behavior. Neurosci Biobehav Rev. 1995 Spring;19(1):19-38. doi: 10.1016/0149-7634(94)00020-2. PMID: 7770195.
4. Ellenbroek BA. Histamine H₃ receptors, the complex interaction with dopamine and its implications for addiction. Br J Pharmacol. 2013 Sep;170(1):46-57. doi: 10.1111/bph.12221. PMID: 23647606; PMCID: PMC3764848.
5. Thomas E Scammell, Alexander C Jackson, Nicholas P Franks, William Wisden, Yves Dauvilliers, Histamine: neural circuits and new medications, Sleep, Volume 42, Issue 1, January 2019, zsy183, https://doi.org/10.1093/sleep/zsy183